Stem Cells Spur New Eggs in Ovaries of Adult Mice
By Amanda Gardner
SUNDAY, April 12 (HealthDay News) — Researchers in China have demonstrated that female ovaries may be capable of producing new eggs in adulthood and subsequently producing offspring.
That runs counter to the long-held belief that female mammals, including humans, are born with a finite number of the eggs (oocytes) needed to produce offspring.
According to study senior author Ji Wu, a professor at Shanghai Jiao Tong University, the findings may lead to techniques for the “generation of new oocytes to postpone normal or premature ovarian failure or for the treatment of infertility.”
Paul Sanberg, a stem cell researcher and distinguished professor of neurosurgery and director of the University of South Florida Center for Aging and Brain Repair in Tampa, called the study “fascinating.”
“These stem cells are continuous,” explained Sanberg, who was not involved in the research. “They were still around through life and actually transformed to make oocytes. Then they were transplanted into infertile females and produced offspring.”
Could doctors someday use stem cells to help adult women produce brand-new oocytes? One reproductive medicine expert isn’t sure.
The new finding is “very, very exciting and opens up a big area of discussion,” said Dr. George Attia, associate professor of reproductive endocrinology and infertility at the University of Miami Miller school of Medicine. “If it would ever come to fruition in humans, I really don’t know. It’s far, far out there,” he said.
Another expert agreed.
“It’s a cute experiment, but I don’t think it’s going to have anything to do with humans,” said Dr. Darwin J. Prockop, director of the Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott & White. “There are too many steps, too many things could go wrong.”
But the findings, published online April 12 in Nature Cell Biology, could still have interesting implications for future stem cell and other research, Prockop added. “Any new kind of cell is interesting,” he said.